Product Description

Profilin-2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60364-50, BS60364-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Profilins (Profilin-1, Profilin-2 and Profilin-3) act as nucleotide exchange factors that use ATP to charge Actin, a process that regμlates Actin polymerization by subsequently sequestering the Actin monomer. Profilin-2, also known as PFN2 or PFL, is a 140 amino acid protein that is ubiquitously expressed with highest expression in kidney, brain and skeletal muscle. Like other members of the Profilin family, Profilin-2 functions as an Actin monomer-binding protein that influences the structure of the cytoskeleton by regμlating Actin polymerization in response to extracellμlar signals. High levels of Profilin-2 inhibit Actin polymerization, while lower levels enhance Actin polymerization, suggesting that the expression of Profilin-2 is regμlated by the need for polymerization within the cell. Two isoforms of Profilin-2 exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Profilin2, Profilin 2, Profilin II, PFN2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human Profilin-2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Profilin-2 polyclonal antibody detects endogenous levels of Profilin-2 protein.

Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35080

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only