Product Description

Protein Phosphatase 4C Mouse Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11900-50, RA11900-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:A phosphoprotein + H (2)O = a protein + phosphate., cofactor:Binds 1 iron ion per subunit., cofactor:Binds 1 manganese ion per subunit., function:Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase., similarity:Belongs to the PPP phosphatase family., similarity:Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily., subunit:Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.,

Reactivity: Human

Host: Mouse

Applications: WB, IHC, ICC

Alternate Names: PP X, PP-X, PP4, PP4C, PP4C, PP4C_HUMAN, PPH3, PPP4, ppp4c, PPX, protein phosphatase 4 (formerly X), catalytic subunit, Protein phosphatase 4 catalytic subunit, Protein phosphatase X, Protein phosphatase X, protein phosphatase X, catalytic subunit, Serine/threonine protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 4 catalytic subunit.

Clonality: Monoclonal

Dilution: wb 1:200 icc 1:200

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Human Gene ID: 5531

Protein Molecular Weight（KDa): 34

Molecular Weight: 34

Research Use Only