PSGL-1 rabbit pAb - ES4302

PSGL-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4302-50, ES4302-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011],

Alternate Name: SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELPLG. AA range:1-50

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 45 110kd (glycosylated)

Human Gene ID: 6404

Human SWISS Prot NO: Q14242

Subcellular Location: Membrane; Single-pass type I membrane protein.

Research Use Only