Product Description

PSIP1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS71250-50, BS71250-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75475

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Background: The lens epithelium-derived growth factor (LEDGF), also designated p75p52, is a transcriptional coactivator that complexes with the human immunodeficiency virus type 1 (HIV-1) integrase. LEDGF/p75p52 is essential for the nuclear localization and chromosomal association of viral proteins. As the primary integrase-to-chromatin tethering factor for HIV-1, LEDGF/p75p52 is responsible for the cellular trafficking of lentiviral integrases. During apoptosis, LEDGF/p75p52 is cleaved at three sites by caspase-3 and caspase-7, contributing to the pathogenesis of atopic disorders.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PSIP1 polyclonal antibody detects endogenous levels of PSIP1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry of paraffin-embedded rat testis using PSIP1 antibody.

Alternative Name: p52; p75; PAIP; DFS70; LEDGF; PSIP2;

Immunogen: Recombinant protein of human PSIP1.

Conjugate: Unconjugated

Modification: Unmodified