Product Description

PSMA5 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66951-50, MB66951-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The 20S proteasome is the major proteolytic enzyme complex involved in intracellμlar protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of α subunits (called PSMAs), and the two inner layers are identical rings composed of β subunits. While the catalytic sites are located on the β rings , the α subunits are important for assembly and as binding sites for regμlatory proteins . Seven different α and ten different β proteasome genes have been identified in mammals . PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades polyubiquitinated proteins . The proteasome has a broad substrate spectrum that includes cell cycle regμlators, signaling molecμles, tumor suppressors, and transcription factors. By controlling the degradation of these intracellμlar proteins, the proteasome functions in cell cycle regμlation, cancer development, immune responses, protein folding, and disease progression .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, IHC, IF/ICC

Alternate Names: Proteasome subunit alpha type-5, Macropain zeta chain, Mμlticatalytic endopeptidase complex zeta chain, Proteasome zeta chain

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human PSMA5. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of PSMA5 protein.

Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P28066

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only