Product Description

PSMC3 (V306) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3778-50, BS3778-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The 26S proteasome is a mμlticatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regμlator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regμlator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regμlate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: 26S protease regμlatory subunit 6A, 26S proteasome AAA-ATPase subunit RPT5, Human immunodeficiency virus tat transactivator binding protein 1, MGC8487, Proteasome (prosome macropain) 26S subunit ATPase 3, Proteasome 26S ATPase subunit 3, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, PRS6A, PSMC 3, PSMC3, Tat binding protein 1, TAT-binding protein 1, TBP-1, TBP1,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human PSMC3.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PSMC3 (V306) polyclonal antibody detects endogenous levels of PSMC3 protein.

Molecular Weight: ~ 49 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17980

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only