PSMC4 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2505-20, A2505-100
Citations, Manuals and SDS Available upon request.
Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms: S6; RPT3; TBP7; TBP-7; MIP224; PSMC4
GeneID: 5704
Swiss-Prot: P43686
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IF/ICC
Calculated Molecular Weight: 47kDa
Observed Molecular Weight: 50kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human PSMC4 (NP_006494.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Ubiquitin, Endocrine Metabolism
Recommended Dilutions: WB: 1:100 - 1:500 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus
Positive Samples: HeLa, Jurkat, 293T, Mouse lung, Rat brain
Keywords: 5704, sc-46465, sc-98797, MB67 interacting protein, MIP224, PSMC4, S6, Tat binding protein 7, TBP 7, TBP7, RPT3, TBP-7, proteasome 26S subunit, ATPase 4, 26S protease regulatory subunit 6B, 26S proteasome AAA-ATPase subunit RPT3, MB67-interacting protein, Tat-binding protein 7, protease 26S subunit 6, proteasome (prosome, macropain) 26S subunit, ATPase, 4, P43686, Proteasome 26S Subunit, Tat-Binding Protein 7, Proteasome (Prosome, Macropain) 26S Subunit, 26S Proteasome AAA-ATPase Subunit RPT3, MB67-Interacting Protein, Protease 26S Subunit 6, 26S Proteasome Regulatory Subunit 6B, 26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, MB67 Interacting Protein, sc46465, sc 46465, sc98797, sc 98797
Symbol: PSMC4
Category: Polyclonal Antibodies
Research Use Only