PSMD1 Rabbit Polyclonal Antibody - BT-AP04318

PSMD1 Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04318-20, BT-AP04318-50, BT-AP04318-100

Citations, Manuals and MSDS Available upon request.

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes| a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base| which contains 6 ATPase subunits and 2 non-ATPase subunits| and a lid| which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid| which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Cell biology; Signal transduction

Target Protein: PSMD1

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PSMD1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q99460; Mouse: Q3TXS7; Rat: O88761

Synonyms: PSMD1; 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112

GeneID: Human: 5707; Mouse: 70247; Rat: 83806

Research Use Only