PSMD8 rabbit pAb - ES13880

PSMD8 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES13880-50, ES13880-100

Citations, Manuals and MSDS Available upon request.

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human PSMD8 AA range: 1-51

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5714

Human SWISS Prot NO: P48556

Subcellular Location: proteasome complex, nucleus, nucleoplasm, cytosol, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, proteasome accessory complex, extracellular exosome,

Research Use Only