Product Description

PSME3 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0010-50, MB0010-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P61289

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB: 1:1000

Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of PSME3 and does not cross-react with related proteins

Bioworld Molecular Weight: Predicted band size:30KDa
Observed band size:34Kda

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western BlotDetection of PSME3 in HepG2, Jurkat & K562 cell lysate (1:1000 diluted).

Alternative Name: Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma; PSME3

Immunogen: Recombinant full length Human PSME3.

Conjugate: Unconjugated

Modification: Unmodified