Product Description

PTEN (7H2) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3286-50, MB3286-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P60484

Host: Mouse

Reactivity: Human

Applications: IHC-P

All Applications: IHC: 1/50-1/100

Background: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using PTEN antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.

Specificity: IgG1

Alternative Name: PTEN; MMAC1; TEP1; Phosphatidylinositol 3; 4; 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog

Immunogen: Synthetic peptide conjugated to KLH.

Conjugate: Unconjugated

Modification: Unmodified