Product Description

PTEN (D386) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5534-50, BS5534-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in mμltiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm, and it shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: DEC, GLM2, ITGA 2, MHAM, MMAC 1, MMAC1, MMAC1, PTEN 1, Pten, PTEN, PTEN1, Tensin homolog, TEP 1, TEP1, TEP1, VLA 2 Receptor Alpha Subunit,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PTEN (D386) polyclonal antibody detects endogenous levels of PTEN protein.

Molecular Weight: ~ 54 kDa

Pathway: Phosphoinosotode Signaling, PI3K AKT signaling, Translational Contral elF4 and p70 S6 Kinase, Regμlation of Microtubμle Dynamics, Inhibition of Apoptosis, Insμlin &Glucose Signaling, MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P60484

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only