Product Description

PTEN Mouse Monoclonal Antibody (2C10)

Sizes: 50μL, 100μL

Catalogue Numbers: RA11906-50, RA11906-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: phosphatase and tensin homolog (PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener

Reactivity: Human

Host: Mouse

Applications: IHC-p, IF(paraffin section)

Alternate Names: PTEN

Clonality: Monoclonal

Dilution: IHC 1:100-200

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Human Gene ID: 5728

Protein Molecular Weight（KDa): 54

Molecular Weight: 54

Research Use Only