PTK2B Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A16045-20, A16045-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 116kDa
Observed Molecular Weight: 116kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 2185
SWISS: Q14289
Alternate Names: PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK; PTK2B
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, Kinase, Tyrosine kinases, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Endocrine Metabolism, Immunology Inflammation, B Cell Receptor Signaling Pathway.
NCBI Alias: PTK2B
Research Use Only