PTN Monoclonal Antibody-MB11480

PTN Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11480-50, MB11480-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P21246

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IP,

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 19 kDa; Observed MW: 19 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PTN in U87-MG lysates using PTN antibody., Western blot analysis of PTN in C6, rat Brain lysates using PTN antibody.

Alternative Name: PTN; HBNF1; NEGF1; Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1

Immunogen: A synthetic peptide of human PTN

Conjugate: Unconjugated

Modification: Unmodified