Product Description

PTN Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7504-50, BS7504-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P21246

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Background: Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTNgene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PTN polyclonal antibody detects endogenous levels of PTN protein.

Bioworld Molecular Weight: ~19 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of PTN polyclonal antibody

Alternative Name: HARP;
HB-GAM;
HBBM;
HBGAM;
HBGF-8;
HBGF8;
HBNF;
HBNF-1;
HBNF1;
heparin affin regulatory protein;
Heparin binding growth associated molecule;
Heparin Binding Growth Factor 8;
Heparin binding neurite outgrowth promoting factor 1;
Heparin-binding brain mitogen;
heparin-binding growth associated molecule;
Heparin-binding growth factor 8;
Heparin-binding growth-associated molecule;
Heparin-binding neurite outgrowth-promoting factor 1;
NEGF1;
Neurite Growth Promoting Factor 1;
Neurite outgrowth-promoting factor, heparin-binding;
OSF-1;
OSF1;
Osteoblast-specific factor 1;
osteoblast-specific factor;
pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1);
Pleiotrophin;
PTN;
PTN_HUMAN;

Immunogen: Recombinant full length Human PTN.

Conjugate: Unconjugated

Modification: Unmodified