PTP1B Polyclonal Antibody - BT-AP07491

PTP1B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07491-20, BT-AP07491-50, BT-AP07491-100

Citations, Manuals and MSDS Available upon request.

Background: Protein tyrosine phosphatase, non-receptor type 1 by PTPN1 is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for PTPN1.

Research Areas: Signal Transduction

Target Protein: PTPN1

Applications: WB, IHC-p, ELISA

Reactivity: Human, Mouse, Rat, Monkey

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PTP1B Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 49967

UniProt Accession: Human: P18031; Mouse: P35821; Rat: P20417

Synonyms: PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B

GeneID: Human: 5770; Mouse: 19246; Rat: 24697

Research Use Only