PTPN11 Monoclonal Antibody - BT-MCA2963

PTPN11 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2963-50, BT-MCA2963-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Research Areas: Signal Transduction

Target Protein: PTPN11

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6D9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PTPN11

Immunogen: Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 68.4kDa

UniProt Accession: Q06124

Synonyms: CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433

GeneID: 5781

Research Use Only