Product Description

PTPRK Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10142-50, ES10142-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein . at AA range: 180-260

Isotype: IgG

Target: PTPRK,

Specificity: PTPRK Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Observed Band (KD): 158kD

Function: Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. PTM: This protein undergoes proteolytic processing. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Similarity: Contains 1 MAM domain. Similarity: Contains 2 tyrosine-protein phosphatase domains. Similarity: Contains 4 fibronectin type-III domains. Tissue Specificity: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Subcellular Location: Cell junction, adherens junction. Cell membrane, Single-pass type I membrane protein.

Storage and Stability: -20°C/1 year

Gene Name: PTPRK, PTPK

Protein Name: Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, EC 3.1.3.48

Human Gene ID: 5796

Human SwissProt Number: Q15262

Mouse SwissProt Number: P35822

Research Use Only