PTRF (Phospho-Tyr156) Rabbit Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA36885-50, RA36885-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, and 0.201% sodium azide.
Store At/In: -20°C/1 year
Recommended Dilutions: WB 1:500-2000
Alternative Names: Polymerase I and transcript release factor (Cavin-1)
Background: polymerase I and transcript release factor (PTRF) Homo sapiens This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrop
Applications: WB
Species Cross-Reactivity: Human; Mouse; Rat
Molecular Weight: 55
GeneID (Human): 284119
Protein MW (KDa): 55
SWISS: Q6NZI2
Source: Rabbit
Research Use Only