PTTG1/2/3 Polyclonal Antibody - BT-AP07507

PTTG1/2/3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07507-20, BT-AP07507-50, BT-AP07507-100

Citations, Manuals and MSDS Available upon request.

Background: Pituitary tumor-transforming 1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. PTTG1 product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for PTTG1.

Research Areas: Cell Biology

Target Protein: PTTG1

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PTTG1/2/3 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 22024

UniProt Accession: Human: O95997; Mouse: Q9CQJ7

Synonyms: PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG

GeneID: Human: 9232

Research Use Only