PTTG1/2/3 Polyclonal Antibody - RA29102

PTTG1/2/3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA29102-50, RA29102-100

Citations, Manuals and MSDS Available upon request.

Background: pituitary tumor-transforming 1 (PTTG1) Homo sapiens The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been fo

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Alternative Names: PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG

Applications: WB; IHC-p; IF/ICC; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 9232

Protein MW (KDa): 30

SWISS: O95997

Source: Rabbit

Research Use Only