Product Description

PUMA Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21437-50, RA21437-100

Citations, Manuals and MSDS Available upon request.

Background: BCL2 binding component 3 (BBC3) Homo sapiens This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Alternative Names: BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis

Applications: WB IF; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 27113

Protein MW (KDa): 23

SWISS: Q9BXH1

Source: Rabbit

Research Use Only