PUMA rabbit pAb - ES3285

PUMA rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3285-50, ES3285-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

Alternate Name: BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis

Source: Rabbit

Applications: WB IF; ELISA

Dilution: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 23kD

Human Gene ID: 27113

Human SWISS Prot NO: Q9BXH1

Subcellular Location: Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.

Research Use Only