Product Description

PVRL1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65668-50, BS65668-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Nectin is a Ca2+-independent homophilic cell adhesion molecμle that belongs to the immunoglobμlin superfamily. Human Nectin is identical to the poliovirus receptor-related protein (PRR) and is identified to be the alphaherpesvirus entry mediator. Nectin constitutes a family consisting of at least nectin 1, 2 and 3. Nectin 2 and 3 are ubiquitously expressed, whereas nectin 1 is abundantly expressed in the brain. Nectin 1 exists as nectin 1å and 1∫/HIgR, produced by alternative splicing. The cytoplasmic regions of Nectin 1å, but not Nectin 1∫/HIgR, have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein, afadin, through which it is linked to the Actin cytoskeleton. Nectin 1, also designated HveC/ PRR1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with nectin 1 is an essential step in the process leading to membrane fusion, the gD binding site is located at the first Ig-like domain of Nectin 1. Both the transinteraction of nectin and the interaction of nectin with afadin are necessary for their co-localization with E-cadherin and catenins at adherens junctions.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit

Host: Rabbit

Applications: IHC-P

Alternate Names: CD111, CD111 antigen, CLPED1, ectodermal dysplasia 4 (Margarita Island type), ED4, Herpes virus entry mediator C, Herpesvirus entry mediator C, Herpesvirus Ig like receptor, Herpesvirus Ig-like receptor, HIgR, HveC, Nectin 1, Nectin-1, Nectin1, OFC7, OROFACIAL CLEFT 7, Poliovirus receptor related protein 1, poliovirus receptor-like 1, Poliovirus receptor-related protein 1, PRR, PRR1, PVRL 1, PVRL1, PVRL1_HUMAN, PVRR, PVRR1, SK-12.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human PVRL1/CD111/Nectin1

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: PVRL1 Polyclonal Antibody detects endogenous levels of PVRL1 protein.

Molecular Weight: 54kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15223

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only