Product Description

PYK2 (phospho-Y580) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4247-50, BS4247-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Pyk2 is a protein tyrosine kinase related to Focal Adhesion Kinase (p125 FAK). Pyk2 is highly expressed in the central nervous system. It is phosphorylated on tyrosine residues in response to various stimμli that elevate intracellμlar calcium concentration, as well as by protein kinase C activation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Cell adhesion kinase beta, CAK beta, Calcium-dependent tyrosine kinase, CADTK, Related adhesion focal tyrosine kinase, RAFTK, PYK2, FAK2, PYK2, RAFTK

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human PYK2 around the phosphorylation site of Tyrosine 580.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-PYK2 (Y580) polyclonal antibody detects endogenous levels of PYK2 protein only when phosphorylated at Tyr580.

Molecular Weight: ~ 116 kDa

Pathway: G Protein-coupled Receptors Signaling to MAPK Erk, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14289

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only