Product Description

Pyruvate Dehydrogenase E2 Mouse Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11913-50, RA11913-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: dihydrolipoamide S-acetyltransferase (DLAT) Homo sapiens This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lact

Reactivity: Human, Mouse

Host: Mouse

Applications: WB, ICC, IP

Alternate Names: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, anti DLAT, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide, Dihydrolipoamide S Acetyltransferase, Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex), Dihydrolipoamide S-Acetyltransferase, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial, DLAT, DLAT, DLTA, E2, E2 component of pyruvate dehydrogenase complex, EC 2.3.1.12, M2 antigen complex 70 kDa subunit, M2 Antigen Complex 70kD Subunit, mitochondrial, ODP2_HUMAN, PBC, PDC E2, PDC-E2, PDCE2, Pyruvate dehydrogenase complex component E2, Pyruvate dehydrogenase complex E2 subunit, S acetyltransferase component of pyruvate dehydrogenase complex.

Clonality: Monoclonal

Dilution: wb 1:1000 icc 1:300

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Human Gene ID: 1737

Protein Molecular Weight（KDa): 69

Molecular Weight: 69

Research Use Only