pyruvate dehydrogenase (lipoamide) α 1 Mouse Monoclonal Antibody - RA11912

pyruvate dehydrogenase (lipoamide) α 1 Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11912-50, RA11912-100

Citations, Manuals and MSDS Available upon request.

Background: pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1) Homo sapiens The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) . The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; ICC

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 5160

Protein MW (KDa): 43

SWISS: P08559

Source: Mouse

Research Use Only