R-spondin1 Monoclonal Antibody - BT-MCA4135

R-spondin1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4135-50, BT-MCA4135-100

Citations, Manuals and MSDS Available upon request.

Background: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Research Areas: Others

Target Protein: R-spondin1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7A6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: R-spondin1

Immunogen: Purified recombinant fragment of R-spondin1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 28.9kDa

UniProt Accession: Q2MKA7

Synonyms: RSPO1, CRISTIN3, FLJ40906

GeneID: 284654

Research Use Only