Product Description

RAB27B Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66707-50, MB66707-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Rab27 proteins are members of the Ras superfamily of small Rab GTPases associated with the process of exocytosis, and in particμlar the exosome secretion pathway. There are two Rab27 isoforms, Rab27A and Rab27B, which are encoded by separate genes and which exhibit distinct subcellμlar localization and functions. Rab27A colocalizes to CD63+ vesicles, whereas Rab27B is observed in perinuclear vesicles. Targeted knockdown studies suggest that the isoforms control distinct steps of the exosome secretion pathway. Rab27A participates in docking and membrane fusion from mμltivesicμlar endosomes (MVEs) to exosomes, whereas Rab27B mediates the transfer of membrane vesicles from the trans-Golgi network to MVEs. It has been suggested that Rab27A and Rab27B may have importance in exosome secretion by cancer cells.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Mouse

Applications: WB, FC

Alternate Names: Ras-related protein Rab-27B, C25KG

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human RAB27B. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), FC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of RAB27B protein.

Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00194

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only