Product Description

RAB3A Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7757-50, BS7757-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Small GTP-binding protein that plays a central role in regμlated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity. Upon stimμlation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicμles onto the plasma membrane (By similarity. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity. Stimμlates insμlin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity. Regμlates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regμlator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regμlation of dopamine release by interacting with synaptotagmin I/SYT (By similarity. Interacts with MADD (via uDENN domain, the GTP-bound form is preferred for interaction (By similarity.

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB, IF/ICC

Alternate Names: RAB3A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human RAB3A(NP_002857.1).

Dilution: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 25kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P20336

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only