Product Description

RAB4A Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB0161-50, MB0161-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies, exhibits 30-60% homology with Ras p21. Accumμlating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticμlum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab family have been identified, each of which is found at a particμlar stage of a membrane transport pathway.

Category: Primary Antibody

Reactivity: Human, Mouse, Monkey

Host: Mouse

Applications: WB, IHC-P, FC

Alternate Names: Ras-related protein Rab-4A, RAB4

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Purified recombinant fragment of human RAB4A expressed in E. Coli.

Dilution: WB: 1/500-1/1000 IHC: 1/100-1/200 FC: 1/50-1/100

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RAB4A monoclonal antibody detects endogenous levels of RAB4A protein.

Molecular Weight: ~ 25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P20338

Product: Purified antibody in PBS with 0.05% sodium azide.

Research Use Only