Rab7B Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11497-50, MB11497-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q96AH8
Host: Rabbit
Reactivity: Human
Applications: WB
All Applications: WB: 1/500-1/1000
Background: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of RAB7B in HelaLysates using Rab7B antibody.
Bioworld Molecular Weight: Calculated MW: 23 kDa; Observed MW: 23 kDa
Specificity: IgG
Alternative Name: RAB7
Immunogen: A synthetic peptide of human RAB7B
Conjugate: Unconjugated
Modification: Unmodified