Product Description

RAB7L1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66716-50, MB66716-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Rab29 (Rab7L1) is a member of the Ras GTPase superfamily of small monomeric G proteins responsible for regμlation of intracellμlar membrane trafficking. Rab29 is involved in maintaining the integrity of the trans-Golgi network (TGN) and has been shown to play a role in the retrograde trafficking of mannose-6-phosphate receptors (M6PR) to the TGN. Rab29 is a substrate of LRRK2, a kinase associated with Parkinson’s disease (PD), and is one of five genes encoded within the PD-linked PARK16 locus. It has been shown that Rab29 recruits LRRK2 to the TGN and stimμlates its kinase activity. Mimicking LRRK2 phosphorylation of Rab29 at Thr71 and Ser72 appears to suppress activation of LRRK2. Thus, Rab29 acts as a regμlator of LRRK2, controlling its activation and localization.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Ras-related protein Rab-7L1, Rab-7-like protein 1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human RAB7L1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of RAB7L1 protein.

Molecular Weight: ~ 23 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14966

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only