Rad50 (Phospho-Ser635) Rabbit Polyclonal Antibody - BT-AP04379

Rad50 (Phospho-Ser635) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04379-20, BT-AP04379-50, BT-AP04379-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50| a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein| cooperating with its partners| is important for DNA double-strand break repair| cell cycle checkpoint activation| telomere maintenance| and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Research Areas: Epigenetics and nuclear signaling

Target Protein: RAD50

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Rad50

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q92878; Mouse: P70388; Rat: Q9JIL8

Synonyms: Rad50;Ser635; DNA repair protein RAD50; hRAD50; EC 3.6.-.-

GeneID: Human: 10111; Rat: 64012

Research Use Only