RASF5 rabbit pAb - ES13460

RASF5 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES13460-50, ES13460-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: WB; IF; ELISA; IHC

Dilution: WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human RASF5 AA range: 234-284

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 83593

Human SWISS Prot NO: Q8WWW0

Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Research Use Only