Product Description

RASSF2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5884-50, BS5884-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Ras is a small GTP-binding protein involved in many cellμlar processes, including proliferation, differentiation and apoptosis. Ras transmits signals of cell surface receptors by binding to a variety of effector molecμles. In addition to the well-characterized effectors Raf and PI-3 kinase, Ras also interacts with a group of homologous, noncatalytic proteins composed of RASSF1, RASSF2, RASSF3, AD037 and Nore1. RASSF1 is a potential tumor suppressor gene that plays an important role in tumor pathogenesis. Nore1 binds to Ras in response to EGF or serum stimμlation, but its function has yet to be determined. RASSF2 is a nuclear protein containing a Ras-associating domain and a SARAH domain. RASSF2 isoform A is inactivated in colorectal cancer cells by CpG island promoter hypermethylation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Ras association domain-containing protein 2, KIAA0168

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 152-197 of Human RASSF2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RASSF2 polyclonal antibody detects endogenous levels of RASSF2 protein.

Molecular Weight: ~ 38 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P50749

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only