Product Description

RASSF8 Polyclonal Antibody

Catalogue Numbers: BS62455-50, BS62455-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: Q8NHQ8

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB

All Applications: WB:1:500~1:1000

Background: RASSF8 (Ras association (RalGDS/AF-6 or RA) domain (N-terminal) family member 8), also known as HoJ-1 (carcinoma-associated protein HoJ-1), is an evolutionarily conserved member of the N-terminal RASSF family which is also comprised of RASSF7, PAMCI (or RASSF9) and RASSF10. RASSF8 contains an N-terminal RA domain and is believed to participate in the Ras signaling pathway. A reciprocal chromosomal translocation involving the genes encoding RASSF8 and Fibulin-1 is associated with a complex form of synpolydactyly, a condition in which there are typically more than five digits on a hand or foot and patients exhibit webbing or fusion of fingers and toes. In addition, RASSF8 is capable of acting as a tumor suppressor in lung cancer, as is suggested by the ectopic expression of RASSF8 inhibiting anchorageindependent growth. This implies that the loss of functional RASSF8 may be implicated in the development of lung cancer.

Purification and Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity: RASSF8 polyclonal antibody detects endogenous levels of RASSF8 protein.

Extra Notes: Western blot (WB) analysis of RASSF8 polyclonal antibody at 1:500 dilution
LaneA:The testis tissue lysate of Rat
LaneB:The testis tissue lysate of Mouse
LaneC:Hela whole cell lysate
LaneD:L02 whole cell lysate

Bioworld Molecular Weight: ~ 45,48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Ras association domain-containing protein 8; Carcinoma-associated protein HOJ-1; RASSF8; C12orf2

Immunogen: Synthetic peptide, corresponding to Human RASSF8.

Conjugate: Unconjugated

Modification: Unmodified