Product Description

RASSF8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62455-50, BS62455-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: RASSF8 (Ras association (RalGDS/AF-6 or RA) domain (N-terminal) family member 8), also known as HoJ-1 (carcinoma-associated protein HoJ-1), is an evolutionarily conserved member of the N-terminal RASSF family which is also comprised of RASSF7, PAMCI (or RASSF9) and RASSF10. RASSF8 contains an N-terminal RA domain and is believed to participate in the Ras signaling pathway. A reciprocal chromosomal translocation involving the genes encoding RASSF8 and Fibμlin-1 is associated with a complex form of synpolydactyly, a condition in which there are typically more than five digits on a hand or foot and patients exhibit webbing or fusion of fingers and toes. In addition, RASSF8 is capable of acting as a tumor suppressor in lung cancer, as is suggested by the ectopic expression of RASSF8 inhibiting anchorageindependent growth. This implies that the loss of functional RASSF8 may be implicated in the development of lung cancer.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Ras association domain-containing protein 8, Carcinoma-associated protein HOJ-1, RASSF8, C12orf2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human RASSF8.

Dilution: WB:1:500~1:1000

Purification: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Specificity: RASSF8 polyclonal antibody detects endogenous levels of RASSF8 protein.

Molecular Weight: ~ 45, 48 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8NHQ8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only