Rb (Phospho-Ser807/811) Rabbit Polyclonal Antibody - BT-AP12238

Rb (Phospho-Ser807/811) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12238-20, BT-AP12238-50, BT-AP12238-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active| hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB)| bladder cancer| and osteogenic sarcoma.

Research Areas: Cancer; Cell biology; Epigenetics and nuclear signaling

Target Protein: RB1

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Rb

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P06400; Mouse: P13405; Rat: P33568

Synonyms: Rb;Ser807/811; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

GeneID: Human: 5925; Mouse: 19645; Rat: 24708

Research Use Only