Rb Polyclonal Antibody - BT-AP07687

Rb Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07687-20, BT-AP07687-50, BT-AP07687-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Research Areas: Cell Biology

Target Protein: RB1

Applications: IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Rb Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 106159

UniProt Accession: Human: P06400; Mouse: P13405; Rat: P33568

Synonyms: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

GeneID: Human: 5925; Mouse: 19645; Rat: 24708

Research Use Only