Rb Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-66997-60, E-AB-66997-120, E-AB-66997-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: Rb
Target Synonym: OSRC; PPP1R130; RB; p105-Rb; pRb; pp110; RB1; Rb
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Rat
Application: IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P06400
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Concentration: 1mg/mL
Immunogen: Recombinant protein of human Rb
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: IF 1:50-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only