Product Description

RBBP6 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8619-50, BS8619-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Rb protein and p53 are both cell cycle checkpoint components. Evidence suggests that p53 plays a role in regμlating the phosphorylation of Rb by inducing p21 transcription, thus preventing Rb phosphorylation at the G1 to S transition. Protein-protein interactions seem to be central in p53 cellμlar activities, as previously demonstrated with MDM2 and SV40 large T antigen. Two novel proteins have been identified by their abilities to bind to p53 and/ or Rb. Human RBQ-1 (also designated RBBP6) has been cloned as a novel protein that binds to the retinoblastoma (Rb) gene product. A related mouse protein, P2P-R, also designated PACT (for p53 associated cellμlar protein-testis derived), has been shown to bind to both Rb and p53. Recombinant P2P-R binds to wildtype p53 but not to mutant p53, and it can interfere with p53 specific DNA binding. RBQ-1 may be a truncated human form of the P2P-R protein.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: IF

Alternate Names: E3 ubiquitin-protein ligase RBBP6, EC=6.3.2.-, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated cellμlar protein of testis, RBBP6, P2PR, PACT, RBQ1, My038

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human RBBP6.

Dilution: IF 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RBBP6 polyclonal antibody detects endogenous levels of RBBP6 protein.

Molecular Weight: ~ 160kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q7Z6E9

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only