Rec8 rabbit pAb - ES8151

Rec8 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8151-50, ES8151-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],

Alternate Name: REC8; REC8L1; Meiotic recombination protein REC8 homolog; Cohesin Rec8p

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human REC8. AA range:154-203

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 62kD

Human Gene ID: 9985

Human SWISS Prot NO: O95072

Subcellular Location: Nucleus. Chromosome. Chromosome, centromere. In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localized to centromeres and spindle poles in endopolyploid tumor cells.

Research Use Only