Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag) - PKSQ050044

Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSQ050044-10, PKSQ050044-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD40; TNFRSF5

Target Synonym: Tumor Necrosis Factor Receptor Superfamily member 5; B-Cell Surface Antigen CD40; Bp50; CD40L Receptor; CDw40; CD40; TNFRSF5

UNIProt ID: G7PG38

Target Species: Cynomolgus macaques

Expression Host: HEK293 Cells

Fusion Tag: C-Fc

Accession: G7PG38

Background: CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.

Sequence: Glu21-Arg193

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 46.3 kDa

Observed MW: 30&35&60 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only