Recombinant Doublecortin Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81552-50, E-AB-81552-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Doublecortin
Target Synonym: DBCN; Dbct; DC; DCX; DCX; Doublecortex; Doublin; FLJ51296; Lis X; Lis-X; Lissencephalin X; Lissencephalin-X; Lissencephaly X linked; Lissencephaly X linked doublecortin; LISX; Neuronal migration protein doublecortin; OTTHUMP00000023859; OTTHUMP00000023860; OTTHUMP00000216315; OTTHUMP00000216316; SCLH; XLIS
Research Areas: Cancer, Neuroscience, Tags and Cell Markers
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Rat
Application: WB
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R05-5B4
UNIProt ID: O43602
Background: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Concentration: 300 μg/mL
Immunogen: Recombinant protein of human Doublecortin
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000
Calculated MW: 41kDa
Observed MW: 41kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only