Recombinant Human ABCG2 protein (His tag)
Size: 100μg
Catalogue Numbers: PDEH100426-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: ABCG2
Target Synonym:
Broad substrate specificity ATP-binding cassette transporter ABCG2; ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338
UNIProt ID: Q9UNQ0
Research Areas: Cancer; Metabolism;
Neuroscience; Signal Transduction; Stem Cells;
Biochemicals
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
Accession: Q9UNQ0
Background: Hematopoietic stem cells are known to express a membrane transporter molecule, known as P-glycoprotein (Pgp), that is encoded by the multidrug resistance gene 1 (MDR1). Expression of Pgp appears to confer a proliferative advantage to stem cells through its anti-apoptotic effects. An additional transporter molecule known as ABCG2 (ATP-binding cassette gene 2) or Bcrp1 (Breast cancer resistance protein 1), first identified in a breast cancer cell line, is expressed on stem cells. ABCG2 belongs to a family of molecules that span the cell membrane six times and can exist as either homo or hetero dimers linked by a short intracellular flexible linker region that plays an important role in the efflux of a wide range of substrates
Sequence: Met 1-Gly 300
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 32.89 kDa
Observed MW: 32 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only