Recombinant Human Activin Receptor 2B/ACVR2B Protein (Fc & His Tag)(Active) - PKSH032041

Recombinant Human Activin Receptor 2B/ACVR2B Protein (Fc & His Tag)(Active)

Size: 50μg

Catalogue Number: PKSH032041-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: Activin Receptor 2B; ACVR2B

Target Symptom: Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B; Bone Morphogenetic Protein Receptor Type-2; BMP Type-2 Receptor; BMPR-3; Bone Morphogenetic Protein Receptor Type II; BMP Type II Receptor

Research Area: Signal Transduction; Stem cells

Target Species: Human

Expression Host: HEK293 Cells

Application: ELISA

Fusion Tag: C-Fc-6His

UNIProt ID: Q13705

Accession: Q13705

Background: Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.

Activity: Immobilized Human/Mouse/Rat Activin A(Cat: PKSH033807) at 5μg/ml(100 μl/well) can bind Human ACVR2B-His. The ED50 of Human ACVR2B-His is 20.58 ng/ml.

Sequence: Ser19-Thr134

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 41.3 kDa

Observed MW: 60 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only