Recombinant Human B7-H2/ICOSLG/CD275 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP00385-10, RP00385-20, RP00385-50, RP00385-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human B7-H2/ICOSLG/CD275 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp19-Ser258) of human ICOSLG/B7-H2/CD275 (Accession #O75144) fused with a 6×His tag at the C-terminus.
Alternate Names: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS
SWISS: O75144
GeneID: 23308
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Inducible co-stimulator ligand (ICOSL) is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.
Source: HEK293 cells
Tag: N-hFC
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Antigen Sequence: DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAAT
Endotoxin: < 0.01 EU/μg of the protein by LAL method
Research Use Only