Recombinant Human CD30/TNFRSF8 Protein (Fc Tag)
Size: 50μg
Catalogue Numbers: PKSH032213-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: CD30; TNFRSF8
Target Synonym: Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8; D1S166E
UNIProt ID: P28908
Research Areas: Cancer; immunology
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-Fc
Accession: P28908
Background: CD30; also known as TNFRSF8; is a cell membrane protein of the tumor necrosis factor receptor family; which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated; but not by resting; T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Sequence: Phe19-Lys379
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mMNaCl, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 65.2 kDa
Observed MW: 90-120 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only