Recombinant Human CLDN18.2(N-6His,C-Avi)
Sizes: 20μg, 100μg
Catalogue Numbers: PKSH034071-20, PKSH034071-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: CLDN18.2
Target Symptom: Claudin-18.2; CLDN18
Conjugation: Biotinylated
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-6His & C-Avi
UNIProt ID: P56856
Accession: P56856-2
Background: Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2.IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is underinvestigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 8M Urea, 150mM NaCl, 5mM β-ME, pH 8.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 12.6 kDa
Observed MW: 13 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only